روز: 13 خرداد 1402

Ponatinib Basic information Anticancer drug Pharmacological effects Toxic side effect Standard dose Drug Interactions Drug contraindications Product Name: Ponatinib Synonyms: AP24534(Ponatinib);3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide;AP24534;AP24534;PONATINIB;3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE;Ponatinib;3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide;Ponatinib (AP24534);Ponatinib (with 4 ints.) CAS: 943319-70-8 MF: C29H27F3N6O MW: 532.56 EINECS: 1308068-626-2 Product Categories: Inhibitors;Pharmaceuticals;Tyrosine Kinase Inhibitors;Potent multi-kinase and pan-BCR-ABL inhibitor.;Heterocycles;Intermediates & Fine Chemicals;API;943319-70-8 Mol File: 943319-70-8.mol Ponatinib Chemical Properties Melting point  >175°C (dec.) density  1.3 storage temp.  -20°C… ادامه خواندن Ponatinib

Lenvatinib Basic information Thyroid cancer drugs Biological activity In vitro study In vivo studies Feature Product Name: Lenvatinib Synonyms: 4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide;E7080 (Lenvatinib);ER-203492-00;1-(4-(6-carbamoyl-7-methoxyquinolin-4-yloxy)-2-chlorophenyl)-3-cyclopropylurea;4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide XEN445;E70801-(4-(6-carbamoyl-7-methoxyquinolin-4-yloxy)-2-chlorophenyl)-3-cyclopropylurea;4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide methanesulfonate;LENVATINIB CAS: 417716-92-8 MF: C21H19ClN4O4 MW: 426.85 EINECS: 1592732-453-0 Product Categories: Inhibitors;FGF receptor antagonist;API;417716-92-8;Intermediate Mol File: 417716-92-8.mol Lenvatinib Chemical Properties Melting point  >216°C (dec.) Boiling point  627.2±55.0 °C(Predicted) density  1.46 storage temp.  -20°C solubility  Soluble in DMSO… ادامه خواندن Lenvatinib

ONDANSETRON HYDROCHLORIDE Basic information Product Name: ONDANSETRON HYDROCHLORIDE Synonyms: sn307;thyl)-,hydrochloride,hydrate(1:1:2);1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one hydrochloride dihydrate;4H-Carbazol-4-one,1,2,3,9-tetrahydro-9-Methyl-3-[(2-Methyl-1H-iMidazol-1-yl)Methyl]-,hydrochloride (1:1);1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-iMidazol-1-yl)Methyl]-4H-carbazol-4-one Hydochloride;EMeset;Osetron;Paroxetine EP IMpurity A CAS: 99614-01-4 MF: C18H20ClN3O MW: 329.82 EINECS: Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor;Amines;Heterocycles;Inhibitors Mol File: 99614-01-4.mol ONDANSETRON HYDROCHLORIDE Chemical Properties Melting point  178.5-179.5°C storage temp.  Inert atmosphere,Store in freezer, under -20°C solubility  H2O: >5 mg/mL pka… ادامه خواندن ONDANSETRON HYDROCHLORIDE

LY 294002 HYDROCHLORIDE Basic information Product Name: LY 294002 HYDROCHLORIDE Synonyms: LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;LY 294002, 99+%;LY294002HCl CAS: 154447-36-6 MF: C19H17NO3 MW: 307.34 EINECS: 1312995-182-4 Product Categories: Inhibitors;Inhibitor;Anti-cancer&immunity;PI3K/Akt/mTOR;Akt;mTOR;PI3K;Cell Cycle Regulation;apis;Signalling;Lipid signaling;PI3K/Akt Signaling Mol File: 154447-36-6.mol LY 294002 HYDROCHLORIDE Chemical Properties Melting point  183-185℃ Boiling point  494.6±45.0 °C(Predicted) density  1.266 storage temp.  Sealed in dry,Store… ادامه خواندن LY 294002 HYDROCHLORIDE

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Basic information Product Name: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Synonyms: (R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE;N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone;(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2-one;(-)-4-Benzyl-3-propionyl-2-oxazolidinone;(4R)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one;(4R)-4-Benzyl-3-propionyloxazolidin-2-one CAS: 131685-53-5 MF: C13H15NO3 MW: 233.26 EINECS: Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Oxazolidinone;chiral;Asymmetric Synthesis;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry;Peptide;Asymmetric Synthesis;Chiral Auxiliaries;Oxazolidinone Derivatives Mol File: 131685-53-5.mol (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Chemical Properties Melting point  45 °C Boiling point  396.6±11.0 °C(Predicted) density  1.206±0.06 g/cm3(Predicted) refractive index  -103 ° (C=1,… ادامه خواندن (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

10,11-Dimethoxystrychnine Basic information Product Name: 10,11-Dimethoxystrychnine Synonyms: STRYCHNIDIN-10-ONE,2,3-DIMETHOXY;10,11-Dimethystrychnine;10,11-DIMETHOXYSTRYCHNINE;BRUCINE, MICROREAGENT FOR THE DETERMINAT ION OF NITRATE;BRUCINE FREE BASE;BRUCINE:STRYCHNIDIN-10-ONE,2,3-DIMETHOXY;BrucineA.R.;BrucineGr CAS: 357-57-3 MF: C23H26N2O4 MW: 394.46 EINECS: 206-614-7 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;PLATINOL;Alkaloids;Organics;chiral;Miscellaneous Reagents;Biochemistry;for Resolution of Acids;Indole Alkaloids;Optical Resolution;Synthetic Organic Chemistry Mol File: 357-57-3.mol 10,11-Dimethoxystrychnine Chemical Properties Melting point  175-178 °C… ادامه خواندن 10,11-Dimethoxystrychnine

Deslorelin Basic information Product Name: Deslorelin Synonyms: Deslorelin,Deslorelin acetate;GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET;[D-TRP6, DES-GLY10]-LH-RH ETHYLAMIDE;DESORELIN;DESLORELIN;deslorelin acetate;DESLORELIN (HUMAN);DES-GLY10,[D-TRP6]-LH-RH ETHYLAMIDE CAS: 57773-65-6 MF: C64H83N17O12 MW: 1282.48 EINECS: 637-335-2 Product Categories: hormones;Peptide;57773-65-6 Mol File: 57773-65-6.mol Deslorelin Chemical Properties Melting point  >189oC alpha  D24 -61° (c = 0.37 in 0.1M acetic acid) density  1.48±0.1 g/cm3(Predicted) storage temp.  −20°C solubility  Acetic acid (Slightly), DMSO… ادامه خواندن Deslorelin

4-iodo-3-nitrobenzamide Basic information Product Name: 4-iodo-3-nitrobenzamide Synonyms: 4-iodo-3-nitrobenzamide;IND-71677;NSC-746045;BSI-201 (Iniparib);iniparib/NSC-746045;BSI-201, 4-Iodo-3-nitrobenzamide;109775;INIPARIB; NSC-746045; IND-71677; BSI 201; BSI201 CAS: 160003-66-7 MF: C7H5IN2O3 MW: 292.03 EINECS: 685-396-9 Product Categories: Inhibitors;Antineoplastic;Inhibitor Mol File: 160003-66-7.mol 4-iodo-3-nitrobenzamide Chemical Properties Boiling point  344.8±32.0 °C(Predicted) density  2.055±0.06 g/cm3(Predicted) storage temp.  Sealed in dry,Store in freezer, under -20°C solubility  DMSO: soluble5mg/mL, clear pka 14?+-.0.50(Predicted) form … ادامه خواندن 4-iodo-3-nitrobenzamide

CYTISINE Basic information Description Biological Functions References Product Name: CYTISINE Synonyms: LABURNIN;LABURNINE;(1R-5S)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-8H-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE;7,11-DIAZATRICYCLO[7.3.1.0(2,7)]TRIDECA-2,4-DIEN-6-ONE;(-)-Cytisine, (1S,9S)-3,11-Diazatricyclo[7.3.1.03,8]trideca-5,7-dien-4-one, (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2a][1,5]diazocin-8-one;(-)-Cytisine 19000;(1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one;1,5-Methano-8H-pyrido1,2-a1,5diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)- CAS: 485-35-8 MF: C11H14N2O MW: 190.24 EINECS: 207-616-0 Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds;Neurochemicals;Nicotine Derivatives;Inhibitors;CYTITON;natural product;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 485-35-8.mol CYTISINE Chemical Properties Melting point  154-156 °C (lit.) Boiling point … ادامه خواندن CYTISINE

Fudosteine Basic information Product Name: Fudosteine Synonyms: FUDESTEINE;Fudosteine (R)-2-Amino-3-(3-hydroxypropylthio)propionic acid;(2R)-2-amino-3-(3-hydroxypropylsulfanyl)propanoic acid;(2R)-2-amino-3-(3-hydroxypropylthio)propionic acid;(2R)-2-azanyl-3-(3-hydroxypropylsulfanyl)propanoic acid;3-[(3-Hydroxypropyl)thio]alanine;(r)-2-amino-3-(3-hydroxypropylthio)propionic acid;S-(3-HYDROXYPROPYL)CYSTEINE CAS: 13189-98-5 MF: C6H13NO3S MW: 179.24 EINECS: 1592732-453-0 Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Other APIs;Sulfur & Selenium Compounds Mol File: 13189-98-5.mol Fudosteine Chemical Properties Melting point  200-202°C (dec.) Boiling point  354.5±42.0 °C(Predicted) density  1.301±0.06 g/cm3(Predicted) storage temp. … ادامه خواندن Fudosteine