| LY 294002 HYDROCHLORIDE Basic information |
| Product Name: | LY 294002 HYDROCHLORIDE |
| Synonyms: | LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;LY 294002, 99+%;LY294002HCl |
| CAS: | 154447-36-6 |
| MF: | C19H17NO3 |
| MW: | 307.34 |
| EINECS: | 1312995-182-4 |
| Product Categories: | Inhibitors;Inhibitor;Anti-cancer&immunity;PI3K/Akt/mTOR;Akt;mTOR;PI3K;Cell Cycle Regulation;apis;Signalling;Lipid signaling;PI3K/Akt Signaling |
| Mol File: | 154447-36-6.mol |
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| LY 294002 HYDROCHLORIDE Chemical Properties |
| Melting point | 183-185℃ |
| Boiling point | 494.6±45.0 °C(Predicted) |
| density | 1.266 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: >5 mg/mL |
| form | solid |
| pka | 0.55±0.20(Predicted) |
| color | white to off-white |
| Water Solubility | Soluble in DMSO at 5mg/ml. Insoluble in water |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| CAS DataBase Reference | 154447-36-6 |
| Safety Information |
| Safety Statements | 24-25 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| LY 294002 HYDROCHLORIDE Usage And Synthesis |
| Description | LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. |
| Uses | LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). |
| Uses | LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice. |
| Uses | LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. |
| Uses | A potent blocker of PI 3-kinase/Akt signaling. |
| Definition | ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. |
| Biological Activity | A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo . |
| target | p110α |
| References | 1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241 |
| LY 294002 HYDROCHLORIDE Preparation Products And Raw materials |
