| Climbazole Basic information |
| Risks to the environment |
| Product Name: | Climbazole |
| Synonyms: | 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;BAY MEB-6401;Diadimefon;MEB-6401;Climbazole 0.1;1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanon;1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-Butanone |
| CAS: | 38083-17-9 |
| MF: | C15H17ClN2O2 |
| MW: | 292.76 |
| EINECS: | 253-775-4 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Alpha sort;C;CAlphabetic;CI – CLPesticides;Conazoles;Fungicides;Pesticides&Metabolites;Pesticide;38083-17-9 |
| Mol File: | 38083-17-9.mol |
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| Climbazole Chemical Properties |
| Melting point | 96-100°C |
| Boiling point | 447.5±40.0 °C(Predicted) |
| density | 1.17±0.1 g/cm3(Predicted) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.54 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Insoluble in water |
| pka | 5.66±0.22(Predicted) |
| form | neat |
| color | White to Almost white |
| Water Solubility | 58mg/L at 25℃ |
| BRN | 618020 |
| InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
| LogP | 3.83 at 25℃ |
| CAS DataBase Reference | 38083-17-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 |
| WGK Germany | 3 |
| RTECS | EL7085000 |
| HS Code | 29332900 |
| Climbazole Usage And Synthesis |
| Risks to the environment | Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms. |
| Description | (±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff. |
| Chemical Properties | White Solid |
| Uses | Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes. |
| Definition | ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether. |
| Hazard | Moderately toxic by ingestion. Low toxicity by skin contact. |
| Flammability and Explosibility | Nonflammable |
| Side effects | May cause localized irritation of the skin with symptoms including redness, rashes and itching. |
| Climbazole Preparation Products And Raw materials |
| Raw materials | Imidazole–>Pyrazole–>3-Thiophenezoic acid |
| Preparation Products | Methidathion |