Climbazole

Climbazole Basic information
Risks to the environment
Product Name:Climbazole
Synonyms:1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;BAY MEB-6401;Diadimefon;MEB-6401;Climbazole 0.1;1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanon;1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-Butanone
CAS:38083-17-9
MF:C15H17ClN2O2
MW:292.76
EINECS:253-775-4
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Alpha sort;C;CAlphabetic;CI – CLPesticides;Conazoles;Fungicides;Pesticides&Metabolites;Pesticide;38083-17-9
Mol File:38083-17-9.mol
Climbazole Structure
Climbazole Chemical Properties
Melting point 96-100°C
Boiling point 447.5±40.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
vapor pressure 0.001Pa at 25℃
refractive index 1.54
storage temp. Inert atmosphere,Room Temperature
solubility Insoluble in water
pka5.66±0.22(Predicted)
form neat
color White to Almost white
Water Solubility 58mg/L at 25℃
BRN 618020
InChIKeyOWEGWHBOCFMBLP-UHFFFAOYSA-N
LogP3.83 at 25℃
CAS DataBase Reference38083-17-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50/53
Safety Statements 60-61
RIDADR UN 3077
WGK Germany 3
RTECS EL7085000
HS Code 29332900
MSDS Information
Climbazole Usage And Synthesis
Risks to the environmentClimbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.
Description(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Chemical PropertiesWhite Solid
UsesClimbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
DefinitionChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
HazardModerately toxic by ingestion. Low toxicity by skin contact.
Flammability and ExplosibilityNonflammable
Side effectsMay cause localized irritation of the skin with symptoms including redness, rashes and itching.
Climbazole Preparation Products And Raw materials
Raw materialsImidazole–>Pyrazole–>3-Thiophenezoic acid
Preparation ProductsMethidathion

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