| LDAO Basic information |
| Product Name: | LDAO |
| Synonyms: | oxydededimethyllaurylamine;refan;Dodecycldimethylamine oxide;DDAO, Lauryldimethylamine N-oxide, LDAO;n-Dodeycl-N,N-dimethylamine-N-oxide;Barlox(R) 1260;Cocoamine oxide derivative;dodecyl bimethyl amine oxide |
| CAS: | 1643-20-5 |
| MF: | C14H31NO |
| MW: | 229.4 |
| EINECS: | 216-700-6 |
| Product Categories: | Surfactant;Hair Care;Home Care;bc0001;1643-20-5;Glycon Biochem |
| Mol File: | 1643-20-5.mol |
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| LDAO Chemical Properties |
| Melting point | 132-133 °C(lit.) |
| Boiling point | 371.32°C (rough estimate) |
| density | 0.996 g/mL at 20 °C |
| vapor pressure | 0Pa at 25℃ |
| refractive index | n20/D 1.378 |
| Fp | 113°C (closed cup)(235 |
| storage temp. | -20°C |
| solubility | Ethanol:15.0(Max Conc. mg/mL);65.38(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);1.31(Max Conc. mM) DMSO:0.1(Max Conc. mg/mL);0.44(Max Conc. mM) PBS (pH 7.2):0.1(Max Conc. mg/mL);0.44(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.79±0.40(Predicted) |
| Specific Gravity | 0.97 |
| Water Solubility | Insoluble in water. |
| Sensitive | Hygroscopic |
| BRN | 1769927 |
| Stability: | Stable. Incompatible with strong oxidizing agents. Combustible. |
| LogP | 1.85 at 20℃ |
| EPA Substance Registry System | Lauryldimethylamine oxide (1643-20-5) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 34-52/53 |
| Safety Statements | 26-36/37/39-45-27 |
| RIDADR | UN 3259 8/PG 2 |
| WGK Germany | 2 |
| RTECS | JR6650000 |
| F | 3-10 |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29299090 |
| Hazardous Substances Data | 1643-20-5(Hazardous Substances Data) |
| Toxicity | mouse,LD50,intraperitoneal,375mg/kg (375mg/kg),French Medicament Patent Document. Vol. #4264M, |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| LDAO Usage And Synthesis |
| Chemical Properties | Clear yellow Liquid |
| Uses | LDAO is suitable to use in crystallization of membrane proteins. It is also suitable to enhance the detection of high molecular weight proteins. |
| Uses | Barlox(R) 1260 is a concentrated cocoamine oxide surfactant. Barlox(R) 1260 can be used in a broad number of industriual cleaning applications where coupling, high foaming, detergency and compatibility are important. Product Data Sheet |
| Definition | ChEBI: Dodecyldimethylamine N-oxide is a tertiary amine oxide resulting from the formal oxidation of the amino group of dodecyldimethylamine. It has a role as a plant metabolite and a detergent. It derives from a hydride of a dodecane. |
| General Description | Crystalline solid. |
| Air & Water Reactions | Hygroscopic . |
| Reactivity Profile | LDAO is less basic than the tertiary amine from which LDAO is derived, but still reacts with strong acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Fire Hazard | Flash point data for LDAO are not available. LDAO is probably nonflammable. |
| Flammability and Explosibility | Notclassified |
| Biochem/physiol Actions | LDAO can be used to disrupt phospholipid bilayer of cells. |
| Purification Methods | Crystallise the oxide from acetone or ethyl acetate. [Bunton et al. J Org Chem 52 3832 1987, Beilstein 4 III 410, 4 IV 798.] |
| LDAO Preparation Products And Raw materials |
| Raw materials | Hydrogen peroxide–>Dodecylamine |