4-Hexanolide

4-Hexanolide Basic information
Product Name:4-Hexanolide
Synonyms:4-HYDROXYHEXANOIC ACID G-LACTONE;4-hexanolide;4-Ethyl-4-hydroxybutanoic acid lactone;GAMMA-HEXANOLACTONE;gamma-Ethylbutyrolactone;gamma-Ethyl-n-butyrolactone;hexa-4-olide;Hexanoic acid, 4-hydroxy-, gamma-lactone
CAS:695-06-7
MF:C6H10O2
MW:114.14
EINECS:211-778-8
Product Categories:Cosmetics;Food Additive;lactone flavors;Heterocycles
Mol File:695-06-7.mol
4-Hexanolide Structure
4-Hexanolide Chemical Properties
Melting point -18°C
Boiling point 219 °C(lit.)
density 1.023 g/mL at 25 °C(lit.)
vapor pressure 2.4hPa at 20℃
FEMA 2556 | GAMMA-HEXALACTONE
refractive index n20/D 1.439(lit.)
Fp 209 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Colorless to Almost colorless
Specific Gravity1.023
Odorat 10.00 % in dipropylene glycol. herbal coconut sweet coumarin tobacco
Odor Typetonka
Water Solubility 77g/L at 20℃
JECFA Number223
BRN 107260
LogP0.3 at 20℃
CAS DataBase Reference695-06-7(CAS DataBase Reference)
NIST Chemistry Reference2(3H)-Furanone, 5-ethyldihydro-(695-06-7)
EPA Substance Registry System2(3H)-Furanone, 5-ethyldihydro- (695-06-7)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-36
Safety Statements 26-36
WGK Germany 2
RTECS LU4220000
Hazard Note Irritant
TSCA Yes
HS Code 29322090
MSDS Information
ProviderLanguage
SigmaAldrichEnglish
ALFAEnglish
4-Hexanolide Usage And Synthesis
Descriptiongamma-Hexalactone has a warm, powerful, herbaceous, sweet odor and a sweet, coumarin-caramel taste. May be prepared by reduction of sorbic acid using Zn, Sn, or SnCl2 and concentrated HCL in acetic acid solution at 85°C; from ethylene oxide and sodio-malonic ester; also from propyl alcohol and methylacrylate in the presence of di-tert-butyl peroxide.
Chemical Propertiesγ-Hexalactone has a sweet, herbaceous, warm, powerful, odor, with a sweet, coumarin-caramel taste. This compound is also described to have odor as sweet, creamy, lactonic, tobacco and coumarin-like with green coconut nuances.
Chemical Properties4-Hexanolide is clear colorless liquid
OccurrenceReported found in apple juice, apricot, orange juice, guava, raisin, papaya, peach, pineapple, berries, asparagus, peas, potato, tomato, breads, cheeses, butter, milk, chicken fat, cooked beef, cooked pork, beer, cognac, grape wines, cocoa, tea, filberts, pecans, passion fruit, Japanese plum, beans, mushroom, starfruit, mango, dried fig, prickly pear, licorice, soursop, Cape gooseberry, nectarines, quince, pawpaw and other sources.
Uses4-Hexanolide was used as curing agent for diglycidyl ether of bisphenol A with ytterbium triflate as an initiator.
Usesγ-Caprolactone was used as curing agent for diglycidyl ether of bisphenol A with ytterbium triflate as an initiator.
Usesγ-Hexalactone may be used as an analytical standard for the determination of the analyte in wine, fruits, biological samples, meat products, and e-cigarette refill solutions by various chromatography techniques.
PreparationBy reduction of sorbic acid using Zn, Sn or SnCl2 and concentrated HCl in acetic acid solution at 85°C; from ethylene oxide and sodio-malonic ester; also from propyl alcohol and methylacrylate in the presence of di-tert-butyl peroxide
Definition4-Hexanolide is a gamma-lactone that is oxolan-2-one substituted by an ethyl group at position 5.
Aroma threshold valuesDetection: 1.6 ppm
Taste threshold valuesTaste characteristics at 75 ppm: sweet, creamy, vanilla-like with green lactonic powdery nuances
Synthesis Reference(s)Tetrahedron Letters, 28, p. 2111, 1987 DOI: 10.1016/S0040-4039(00)96056-8
General Descriptionγ-Hexalactone is a volatile flavoring compound largely present in food and beverage products, fruits, vegetables, etc.
Biochem/physiol ActionsTaste at 5-10ppm
4-Hexanolide Preparation Products And Raw materials
Preparation ProductsHexanoic acid–>4-OXO-HEXANOIC ACID–>5-HYDROXYMETHYL-FURAN-2-CARBOXYLIC ACID

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