| Triclabendazole Basic information |
| Product Name: | Triclabendazole |
| Synonyms: | FASINEX;CGA-89317;5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-METHYLTHIO-1H-BENZIMIDAZOLE;TRICLABENDAZOLE;5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1h-benzimidazol;5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole, CGA-89317, Fasinex;1H-Benzimidazole, 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-;5-CHLORO-6-(2,3-DICHLOROPHENOXY)-2-(METHYLTHIO)-1H-BENZIMIDAZOL(TRICLABENDAZOLE) |
| CAS: | 68786-66-3 |
| MF: | C14H9Cl3N2OS |
| MW: | 359.66 |
| EINECS: | 614-728-7 |
| Product Categories: | Veterinary drugs;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API’s;Pharmaceutical intermediate;68786-66-3 |
| Mol File: | 68786-66-3.mol |
 |
| Triclabendazole Chemical Properties |
| Melting point | 175-176°C |
| Boiling point | 240.6°C (rough estimate) |
| density | 1.3875 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetonitrile (Slightly, Sonicated), Methanol (Slightly) |
| form | neat |
| pka | 7.91±0.10(Predicted) |
| color | White to Beige |
| Merck | 14,9652 |
| BCS Class | 4/3 |
| Stability: | Stability |
| InChI | InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19) |
| InChIKey | NQPDXQQQCQDHHW-UHFFFAOYSA-N |
| SMILES | C1(SC)NC2=CC(Cl)=C(OC3=CC=CC(Cl)=C3Cl)C=C2N=1 |
| CAS DataBase Reference | 68786-66-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 3 |
| RTECS | DD6747000 |
| HS Code | 29339900 |
| Toxicity | LD50 oral in rabbit: 206mg/kg |
| Provider | Language |
|---|---|
| 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole | English |
| Triclabendazole Usage And Synthesis |
| Description | Triclabendazole is a benzimidazole anthelmintic. It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg. Triclabendazole (5 μM) also protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway. |
| Chemical Properties | Off-White Solid |
| Uses | An anthelmintic (fasciola). |
| Uses | An anthelmintic (fasciola) |
| Uses | Triclabendazole is classified under the category of ‘Anthelmintic flukicide for veterinary use. |
| Definition | ChEBI: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole is an aromatic ether. |
| Triclabendazole Preparation Products And Raw materials |