| Desonide Basic information |
| Product Name: | Desonide |
| Synonyms: | DESONIDE;1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE;(11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione;16-alpha-hydroxyprednisole-16,17-acetonide;17-acetonide,16-alpha-hydroxy-prednisolone-1;d-2083;steroderm;Desonidemicro |
| CAS: | 638-94-8 |
| MF: | C24H32O6 |
| MW: | 416.51 |
| EINECS: | 211-351-6 |
| Product Categories: | SPORANOX;Hormone Drugs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API |
| Mol File: | 638-94-8.mol |
 |
| Desonide Chemical Properties |
| Melting point | 272-274?C |
| Boiling point | 580.1±50.0 °C(Predicted) |
| density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 12.87±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 638-94-8(CAS DataBase Reference) |
| Safety Information |
| HS Code | 2937290000 |
| Toxicity | LD50 in rats (mg/kg): 93 s.c. (Phillips) |
| Provider | Language |
|---|---|
| Desonide | English |
| Desonide Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Originator | Tridesilon,Dome,US,1972 |
| Uses | antifungal |
| Uses | Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory. |
| Uses | Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490). |
| Indications | Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid. |
| Definition | ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders. |
| Manufacturing Process | Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3×25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C. |
| Brand name | Desowen (Galderma); Tridesilon (Perrigo). |
| Therapeutic Function | Antiinflammatory |
| Desonide Preparation Products And Raw materials |