BERBERINE CHLORIDE

BERBERINE CHLORIDE Basic information
Product Name:BERBERINE CHLORIDE
Synonyms:5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride hydrate;Berberine chloride hydrate, 97%, water <17%;Berberine (berberine hydrochloride);9,10-DiMethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-iuM chloride hydrate;Berberine chloride hydrate technical, >=90% (AT);LABOTEST-BB LT00440956;CI 75160;BERBERINE HYDROCHLORIDE N-HYDRATE
CAS:141433-60-5
MF:C20H20ClNO5
MW:389.83
EINECS:211-195-9
Product Categories:Alkaloids;Biochemistry;Miscellaneous Natural Products;Isoquinoline Alkaloids
Mol File:141433-60-5.mol
BERBERINE CHLORIDE Structure
BERBERINE CHLORIDE Chemical Properties
Melting point 204-206 °C (dec.)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
Colour Index 75160
color Pale Yellow to Yellow
Water Solubility Soluble in water.
Sensitive Light Sensitive
Merck 14,1154
BRN 3836585
Stability:Hygroscopic
InChIKeyVKJGBAJNNALVAV-UHFFFAOYSA-M
CAS DataBase Reference141433-60-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
WGK Germany 2
RTECS DR9866400
3-10
TSCA Yes
HS Code 29399990
MSDS Information
ProviderLanguage
SigmaAldrichEnglish
BERBERINE CHLORIDE Usage And Synthesis
DescriptionThis alkaloid occurs together with Neprotine (q.v.) in Berberis insignis Hook, B. umbellata Wall and Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng.). It is optically inactive and crystallizes from H2O with 5.5 H2O. It yields crystal_x0002_line salts, e.g. the nitrate, m.p. 265-7°C (dec.); sulphate, m.p. 271-3°C (dec.) and the picrate, m.p. 231°C (dec.). The base also furnishes a methyl ether, m.p. 265°C and on catalytic hydrogenation gives the tetrahydro derivative, m.p. 213-5°C (dec.). The ultraviolet spectrum resembles that of berberine (q.v.). Oxidation with KMn04 in Me2CO gives hemipinic acid, identified as the ethylimide, m.p. 90°C.
UsesPrimarily for the treatment of gastroenteritis, dysentery and other intestinal infections and conjunctivitis, purulent otitis media.
ReferencesOrekhov.,J. Amer. Pharm. Assoc., 30,247, (1941)
Chatterjee., ibid, 33,205,210 (1944)
BERBERINE CHLORIDE Preparation Products And Raw materials
Preparation ProductsBerberine

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