2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Basic information
Product Name:2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms:AKOS 92835;2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-2-HYDROXYMETHYLPYRROLIDINE;tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate;(±)-1-Boc-pyrrolidine-2-Methanol;1-Boc-(2-HydroxyMethyl)pyrrolidine;N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol;N-Boc-2-pyrrolidineMethanol
CAS:170491-63-1
MF:C10H19NO3
MW:201.26
EINECS:
Product Categories:pharmacetical
Mol File:170491-63-1.mol
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Structure
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties
Melting point 52-54℃
Boiling point 290℃
density 1.084
Fp 129℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Methanol
pka14.77±0.10(Predicted)
form powder to crystal
color White to Almost white
InChIKeyBFFLLBPMZCIGRM-UHFFFAOYSA-N
CAS DataBase Reference170491-63-1
Safety Information
Risk Statements 36/37/38
Safety Statements 26-37
HS Code 29339900
MSDS Information
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis
UsesN-(tert-Butoxycarbonyl)pyrrolidine-2-methanol is used to prepare 1,3-thiazolidin-2-imines derivatives as inhibitors of nitric oxide synthase.
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials1-Boc-3-hydroxymethylpyrrolidine–>homoproline–>D(-)Prolinol–>2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER–>1-N-BOC-2,3-DIHYDRO-PYRROLE –>Methyl 1-Boc-5-oxopyrrolidine-2-carboxylate–>2-(Hydroxymethyl)pyrrolidine–>carbon monoxide–>Di-tert-butyl dicarbonate–>DL-Proline–>L-(+)-Prolinol–>Bromochloromethane–>1-Boc-Pyrrolidine–>BOC-L-Proline
Preparation Products1-Methylpyrrolidine-2-methanol

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