| 4-(Methylsulfonyl)phenol Basic information |
| Product Name: | 4-(Methylsulfonyl)phenol |
| Synonyms: | 4-METHANESULFONYL-PHENOL;4-(methylsulfonyl)-pheno;4-Hydroxyphenyl methyl sulfone;4-hydroxyphenylmethylsulfone;p-(methylsulfonyl)-pheno;p-(Methylsulfonyl)phenol;Phenol, 4-(methylsulfonyl)-;Phenol, p-(methylsulfonyl)- |
| CAS: | 14763-60-1 |
| MF: | C7H8O3S |
| MW: | 172.2 |
| EINECS: | 632-596-9 |
| Product Categories: | |
| Mol File: | 14763-60-1.mol |
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| 4-(Methylsulfonyl)phenol Chemical Properties |
| Melting point | 90-95 °C |
| Boiling point | 272.52°C (rough estimate) |
| density | 1.3692 (rough estimate) |
| refractive index | 1.5151 (estimate) |
| RTECS | SM1530000 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | pK1:7.83 (25°C) |
| color | Tan to pink-brown |
| Water Solubility | slight |
| BRN | 1866322 |
| LogP | 0.886 (est) |
| CAS DataBase Reference | 14763-60-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-(Methylsulfonyl)phenol(14763-60-1) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 24/25-26 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29309090 |
| Provider | Language |
|---|---|
| 4-Methylsulfonylphenol | English |
| ACROS | English |
| 4-(Methylsulfonyl)phenol Usage And Synthesis |
| Chemical Properties | Tan to pink-brown powder |
| Uses | 4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. |
| Reactions | The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%). |
| 4-(Methylsulfonyl)phenol Preparation Products And Raw materials |