Methyl 3-amino-2-pyrazinecarboxylate

Methyl 3-amino-2-pyrazinecarboxylate Basic information
Product Name:Methyl 3-amino-2-pyrazinecarboxylate
Synonyms:METHYL 2-AMINOPYRAZINE-3-CARBOXYLATE;METHYL 3-AMINO-2-PYRAZINECARBOXYLATE;METHYL 3-AMINOPYRAZINE-2-CARBOXYLATE;BUTTPARK 35\02-15;3-AMINOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;AKOS 90402;TIMTEC-BB SBB004048;methyl 3-aminopyrazinecarboxylate
CAS:16298-03-6
MF:C6H7N3O2
MW:153.14
EINECS:240-387-5
Product Categories:amine| carboxylic ester;Amines;Pyrazinecarboxylic Acid & Derivatives;Heterocycles;Building Blocks;Heterocyclic Building Blocks;Pyrazines;Heterocyclic Compounds;Chemical Amines;Pyrazine
Mol File:16298-03-6.mol
Methyl 3-amino-2-pyrazinecarboxylate Structure
Methyl 3-amino-2-pyrazinecarboxylate Chemical Properties
Melting point 169-172 °C (lit.)
Boiling point 300.8±37.0 °C(Predicted)
density 1.319±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Chloroform, Methanol
pka-0.30±0.10(Predicted)
form Crystalline Powder
color Yellow
BRN 127495
InChIKeyINCSQLZZXBPATR-UHFFFAOYSA-N
LogP0.2 at 20℃ and pH7
Surface tension73.3mN/m at 1g/L and 20℃
CAS DataBase Reference16298-03-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-37/39-26
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
ACROSEnglish
SigmaAldrichEnglish
Methyl 3-amino-2-pyrazinecarboxylate Usage And Synthesis
Chemical Propertiesyellow crystalline powder
UsesMethyl 3-amino-2-pyrazinecarboxylate has been used in:
synthesis of 2-arylpteridin-4-ones and piperazine-derived 2-furan-2-yl-[1,2,4]triazolo[1,5-a] pyrazinesreactions with isocyanates and aroyl chlorides for conversion to pteridinediones
DefinitionChEBI: Methyl 3-aminopyrazine-2-carboxylate is a pyrazine that is substituted by a methoxycarbonyl group at position 2 and an amino group at position 3. It is a member of pyrazines, a methyl ester and an aromatic amine.
Purification MethodsThe ester forms yellow needles from H2O (100 parts using charcoal). If it contains the free acid (see IR), then dissolve it in CH2Cl2, wash it with saturated aqueous Na2CO3, brine, dry over MgSO4 filter, evaporate and recrystallise the residue. The free acid has m 203-204o (dec) [UV: Brown & Mason J Chem Soc 3443 1956] and pK1 <1 and pK2 3.70. The ammonium salt has m 232o(dec) (from aqueous Me2CO) and the amide has m 239.2o (from H2O) [Ellingson et al. J Am Chem Soc 67 1711 1945]. [Beilstein 25 III/IV 4412.]
Methyl 3-amino-2-pyrazinecarboxylate Preparation Products And Raw materials
Preparation Products2-Amino-5-chloropyrazine–>tetrabroMobisphenol-A-polycarbonate–>methyl 3-bromopyrazine-2-carboxylate–>3-AMINOPYRAZINE-2-CARBONITRILE–>Methyl 3-amino-6-chloropyrazine-2-carboxylate–>methyl 3,6-dibromopyrazine-2-carboxylate

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