6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Basic information
Product Name:6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Synonyms:4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINE;ASINEX-REAG BAS 13549338;6–3-(4-)-1,2 KY-16-05;Paliperidone Related CoMpound B;1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1);Paliperidone int 2;Paliperidone Related Compound B (20 mg) (6-fluoro-3-(piperidin-4-yl)benzoisoxazole hydrochloride);Iloperidone intermediate
CAS:84163-13-3
MF:C12H14ClFN2O
MW:256.7
EINECS:700-303-4
Product Categories:APIs Intermediate;Iloperidone Intermediate;Oxazole&Isoxazole;(intermediate of risperidone)
Mol File:84163-13-3.mol
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Structure
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Chemical Properties
Melting point 293-295 °C
density 1.42g/cm3 at 20℃
vapor pressure 0.002-0.005Pa at 20-25℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Very Slightly, Heated), Water (Slightly, Heated)
form Solid
color White to Off-White
LogP-0.84 at 20℃ and pH7
CAS DataBase Reference84163-13-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
HazardClass IRRITANT
HS Code 2934990002
MSDS Information
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Usage And Synthesis
Uses6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent.
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Preparation Products And Raw materials
Raw materials1-Piperidinecarboxaldehyde, 4-(6-fluoro-1,2-benzisoxazol-3-yl)-–>1-Piperidinecarboxaldehyde, 4-[(2,4-difluorophenyl)(hydroxyimino)methyl]-–>1-FORMYL-PIPERIDINE-4-CARBONYL CHLORIDE–>4-(2,4-DIFLUORO-BENZOYL)-PIPERIDINE-1-CARBALDEHYDE–>2,4-Difluorobenzaldehyde–>1-Methylpiperdin-4-ylmagnesium chloride, 0.50 M in THF–>2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime–>2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride–>Isonipecotic acid–>1,3-Difluorobenzene
Preparation ProductsRisperidone–>3-(1-(3-CHLOROPROPYL)PIPERIDIN-4-YL)-6-FLUOROBENZO[D]ISOXAZOLE–>Paliperidone Palmitate

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