| (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Basic information |
| Product Name: | (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester |
| Synonyms: | Posaconazole Impurity 53;((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate;Posaconazole InterMediates;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester- (POA);(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4;Toluene-4-sulfonica cid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester;((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate |
| CAS: | 149809-43-8 |
| MF: | C21H21F2N3O4S |
| MW: | 449.47 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Aromatics;Chiral Reagents;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 149809-43-8.mol |
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| (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Chemical Properties |
| Melting point | 100-102°C |
| Boiling point | 608.1±65.0 °C(Predicted) |
| density | 1.40 |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | slightly sol. in Chloroform |
| pka | 2.75±0.10(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| InChIKey | DFWVLCJRFGIRAK-HRAATJIYSA-N |
| CAS DataBase Reference | 149809-43-8(CAS DataBase Reference) |
| Safety Information |
| (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Usage And Synthesis |
| Chemical Properties | White Crystalline Solid |
| Uses | Posaconazole intermediate. Antifungal agent. |
| Uses | Posaconazole intermediate. Antifungal agent |
| (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Preparation Products And Raw materials |
| Raw materials | Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl–>Tosyl chloride |
| Preparation Products | O-Benzyl Posaconazole |