6-Fluoroquinaldine

6-Fluoroquinaldine Basic information
Product Name:6-Fluoroquinaldine
Synonyms:6-Fluoro-2-methylquinoline, 98+%;6-Fluoro-2-methyl-1-azanaphthalene;AKOS 1002;6-FLUORO-2-METHYLQUINOLINE;6-FLUOROQUINALDINE;6-Fluoro-2-methylquinoline 97%;6-Fluoro-2-methylquinoline97%;2-METHYL-6-FLUOROQUINOLINE
CAS:1128-61-6
MF:C10H8FN
MW:161.18
EINECS:214-439-2
Product Categories:Aromatics Compounds;Quinolines, Quinazolines and derivatives;Quinoline&Isoquinoline;Alkylquinolines;Haloquinolines;Quinolines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Heterocyclic Building Blocks
Mol File:1128-61-6.mol
6-Fluoroquinaldine Structure
6-Fluoroquinaldine Chemical Properties
Melting point 49-53 °C (lit.)
Boiling point 99 °C / 3mmHg
density 1.1465 (estimate)
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in Chloroform.
pka5.16±0.43(Predicted)
form powder to crystal
color White to Almost white
BRN 1281677
CAS DataBase Reference1128-61-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 38-41-36/37/38
Safety Statements 26-37/39-36
WGK Germany 3
Hazard Note Irritant
HS Code 29334990
MSDS Information
ProviderLanguage
SigmaAldrichEnglish
ACROSEnglish
ALFAEnglish
6-Fluoroquinaldine Usage And Synthesis
Chemical Propertiesbrown powder or granules
UsesMetal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Br?nsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.
UsesQuinoline derivative as a highly potent thrombin receptor antagonist
6-Fluoroquinaldine Preparation Products And Raw materials
Raw materials(R)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline–>2-AMINO-5-FLUOROBENZALDEHYDE–>6-Bromo-2-methylquinoline–>6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline–>Ethanol–>Crotonaldehyde–>4-Fluoroaniline–>Acetaldehyde–>Ethyl vinyl ether–>Diacetone Alcohol–>Acetic acid

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