| 1-Chloroisoquinoline Basic information |
| Product Name: | 1-Chloroisoquinoline |
| Synonyms: | 1-Chloroisoquinone;Isoquinoline, 1-chloro-;1-Chloroisoquinoline 95%;1-chloro-1,2-dihydroisoquinoline;1-CHLOROISOQUINOLINE;1-CHLOROISOQUINOLINE, 98.0+%(GC);chloroisoquinoline;1-Chloroisoquinoline,95% |
| CAS: | 19493-44-8 |
| MF: | C9H6ClN |
| MW: | 163.6 |
| EINECS: | 628-561-2 |
| Product Categories: | Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Isoquinolines;Other Products;Heterocyclic Series;Quinolines;IsoquinolinesBuilding Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks |
| Mol File: | 19493-44-8.mol |
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| 1-Chloroisoquinoline Chemical Properties |
| Melting point | 31-36 °C (lit.) |
| Boiling point | 274-275 °C/768 mmHg (lit.) |
| density | 1.2108 (rough estimate) |
| refractive index | 1.6342 (estimate) |
| Fp | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| form | Low Melting Solid, Crystals and/or Chunks |
| pka | 2.03±0.30(Predicted) |
| color | White to yellow |
| Water Solubility | Insoluble in water. |
| BRN | 2996 |
| InChIKey | MSQCQINLJMEVNJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 19493-44-8(CAS DataBase Reference) |
| Safety Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| 1-Chloroisoquinoline Usage And Synthesis |
| Chemical Properties | white to yellow low melting solid, crystals and/or |
| Uses | Used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides.1 Also used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters.2 |
| Uses | 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of stor age and stability of unstable boronic acids. |
| Uses | The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids. |
| 1-Chloroisoquinoline Preparation Products And Raw materials |
| Preparation Products | Isocarbostyril–>ISOQUINOLINE-1-CARBALDEHYDE–>1-Bromoisoquinoline–>1-((TriMethylsilyl)ethynyl)isoquinoline |