| Methyl 3-amino-4-methylthiophene-2-carboxylate Basic information |
| Product Name: | Methyl 3-amino-4-methylthiophene-2-carboxylate |
| Synonyms: | M3A4MT2C;METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLATE;Methyl 3-amino-4-methyl-2-thenoate;METHYL 3-AMINO-4-METHYL-2-THIOPHENECARBOXYLATE;LABOTEST-BB LT00453517;3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER;3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER |
| CAS: | 85006-31-1 |
| MF: | C7H9NO2S |
| MW: | 171.22 |
| EINECS: | 285-060-8 |
| Product Categories: | Thiophenes & Benzothiophenes;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Thiophenes;Esters;Thiophenes & Benzothiophenes;Thiophene&Benzothiophene;Organic acids;API intermediates;Thiophen |
| Mol File: | 85006-31-1.mol |
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| Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties |
| Melting point | 85-88 °C (lit.) |
| Boiling point | 318.6±37.0 °C(Predicted) |
| density | 1.264±0.06 g/cm3(Predicted) |
| Fp | >100°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 1.71±0.10(Predicted) |
| form | Solid |
| color | Pale Yellow |
| Water Solubility | 1g/L at 35℃ |
| BRN | 973196 |
| InChIKey | YICRPERKKBDRSP-UHFFFAOYSA-N |
| LogP | 1.28 |
| CAS DataBase Reference | 85006-31-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-22 |
| WGK Germany | 2 |
| Hazard Note | Irritant |
| HS Code | 29349990 |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| Methyl 3-amino-4-methylthiophene-2-carboxylate Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder |
| Uses | Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B. |
| Application | methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine. 7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate. The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield. |
| Definition | ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid. |
| Methyl 3-amino-4-methylthiophene-2-carboxylate Preparation Products And Raw materials |