| Ethyl 2-chloroacetoacetate Basic information |
| Product Name: | Ethyl 2-chloroacetoacetate |
| Synonyms: | 2-chloro-3-oxo-butanoicaciethylester;2-Chloro-3-oxobutyric acid ethyl ester;Acetoacetic acid, 2-chloro-, ethyl ester;Ethyl 2-chloracetoacetate;ETHYL 2-CHLOROACETOACETATE;ETHYL ALPHA-CHLOROACETOACETATE;ETHYL CHLOROACETOACETATE;2-Chloro-3-oxobutyric acid ethyl |
| CAS: | 609-15-4 |
| MF: | C6H9ClO3 |
| MW: | 164.59 |
| EINECS: | 210-180-4 |
| Product Categories: | Organic synthesis;Aliphatics;C6 to C7;Carbonyl Compounds;Esters;Pharmaceutical Intermediates;Drug Intermediates;bc0001 |
| Mol File: | 609-15-4.mol |
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| Ethyl 2-chloroacetoacetate Chemical Properties |
| Melting point | -80 °C |
| Boiling point | 107 °C/14 mmHg (lit.) |
| density | 1.19 g/mL at 25 °C (lit.) |
| vapor pressure | 49.4-100Pa at 20℃ |
| refractive index | n20/D 1.441(lit.) |
| Fp | 122 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | Liquid |
| pka | 7.92±0.46(Predicted) |
| color | Clear yellow |
| Water Solubility | 17 g/L (20 ºC) |
| BRN | 774278 |
| LogP | 1.2 at 20℃ and pH1-7 |
| Surface tension | 69.4mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 609-15-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4) |
| EPA Substance Registry System | Ethyl 2-chloroacetoacetate (609-15-4) |
| Safety Information |
| Hazard Codes | C,Xn,F |
| Risk Statements | 10-22-34-52/53-36/37/38-36 |
| Safety Statements | 16-26-36/37/39-45-61-37/39 |
| RIDADR | UN 2920 8/PG 2 |
| WGK Germany | 2 |
| F | 19 |
| Hazard Note | Corrosive |
| TSCA | Yes |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29183000 |
| Provider | Language |
|---|---|
| 2-Chloroacetoacetic acid ethyl ester | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Ethyl 2-chloroacetoacetate Usage And Synthesis |
| Chemical Properties | clear bright yellow liquid |
| Uses | Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae. |
| Biochem/physiol Actions | Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity. |
| Ethyl 2-chloroacetoacetate Preparation Products And Raw materials |