| 4-Nitrophenyl chloroformate Basic information |
| Product Name: | 4-Nitrophenyl chloroformate |
| Synonyms: | CHLOROFORMIC ACID 4-NITROPHENYL ESTER;4-NITROPHENYL CHLOROFORMATE;4-Nitrophenyl chloroforMate, 97% 25GR;Formic acid, chloro-, p-nitrophenyl ester;p-Nitrophenoxycarbonyl chloride;ForMic acid, chloro-, p-nitrophenyl ester (6CI,7CI,8CI);4-Nitrophenyl carbonochloridoate, 4-[(Chlorocarbonyl)oxy]nitrobenzene;4-Nitrophenyl Chloroformate >90% |
| CAS: | 7693-46-1 |
| MF: | C7H4ClNO4 |
| MW: | 201.56 |
| EINECS: | 231-706-9 |
| Product Categories: | Pharmaceutical intermediates;Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry;blocks;BuildingBlocks;NitroCompounds;Miscellaneous |
| Mol File: | 7693-46-1.mol |
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| 4-Nitrophenyl chloroformate Chemical Properties |
| Melting point | 77-79 °C(lit.) |
| Boiling point | 159-162 °C19 mm Hg(lit.) |
| density | 1.5719 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| Fp | >110°C |
| storage temp. | 2-8°C |
| solubility | Soluble in acetone, chloroform, acetone, toluene and benzene. |
| form | isopropanol suspension |
| color | White to yellow-beige |
| Water Solubility | decomposes |
| Sensitive | Lachrymatory |
| BRN | 518127 |
| Stability: | Stable. Incompatible with strong bases, acids. Combustible. |
| CAS DataBase Reference | 7693-46-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1) |
| EPA Substance Registry System | Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1) |
| Safety Information |
| Hazard Codes | C,T,Xi,F |
| Risk Statements | 34-36/37-23/24/25-41-36/37/38-11-67-36 |
| Safety Statements | 26-36/37/39-45-38-28A-36-16-27 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| F | 19-21 |
| Hazard Note | Toxic/Corrosive/Lachrymator |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29159020 |
| Provider | Language |
|---|---|
| 4-Nitrophenyl chloroformate | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 4-Nitrophenyl chloroformate Usage And Synthesis |
| Chemical Properties | Cream solid |
| Uses | 4-Nitrophenyl chloroformate can be used: As a reagent for the activation of amines, alcohols and thiols.In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.In the preparation of poly(oxyethylene) modified dextrans.To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. |
| Uses | 4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane. |
| Uses | 4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules. |
| 4-Nitrophenyl chloroformate Preparation Products And Raw materials |