O-TOLUENESULFONYL CHLORIDE

O-TOLUENESULFONYL CHLORIDE Basic information
Product Name:O-TOLUENESULFONYL CHLORIDE
Synonyms:ortho-toluenesulfonylchloride;o-tolylsulfonylchloride;o-Tosyl chloride;o-tosylchloride;toluene-2-sulphonylchloride;ortho-toluenesulfonchloride;o-Toluenesulphonyl chloride;containsca23%isomer)75+%
CAS:133-59-5
MF:C7H7ClO2S
MW:190.65
EINECS:205-113-0
Product Categories:Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Intermediates of Dyes and Pigments
Mol File:133-59-5.mol
O-TOLUENESULFONYL CHLORIDE Structure
O-TOLUENESULFONYL CHLORIDE Chemical Properties
Melting point 10°C
Boiling point 254 °C(lit.)
density 1.320 g/mL at 25 °C(lit.)
refractive index n20/D >1.5580(lit.)
Fp >230 °F
storage temp. Store under inert gas
solubility Acetonitrile (Slightly), Chloroform(Slightly)
form clear liquid
color Colorless to Light yellow
Water Solubility Soluble in hot alcohol, ether and benzene. Reacts with water.
Sensitive Moisture Sensitive
BRN 973180
CAS DataBase Reference133-59-5(CAS DataBase Reference)
EPA Substance Registry SystemBenzenesulfonyl chloride, 2-methyl- (133-59-5)
Safety Information
Hazard Codes C,Xi
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
Hazard Note Corrosive
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 2904100090
Hazardous Substances Data133-59-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrichEnglish
ALFAEnglish
O-TOLUENESULFONYL CHLORIDE Usage And Synthesis
Useso-Toluenesulfonyl chloride is used in organic synthesis and saccharin production. It is also used as pharmaceutical intermediate.
Useso-Toluenesulfonyl chloride may be used in the synthesis of:
oxazolinemesityl o-tolyl sulfoneallyl o-toluenesulfonate2-methyl-4′-t-butyldiphenyl sulfone
General Descriptiono-Toluenesulfonyl chloride can be synthesized by reacting o-thiocresol in glacial acetic acid with chlorine. It participates in the preparation of 5-chloro-3-phenyl-2,1-benzisoxazole.
O-TOLUENESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials2-methylbenzenesulfinic acid–>o-Toluenesulfonic acid, sodium salt–>Carbamothioic acid, diethyl-, S-(2-methylphenyl) ester–>2-Methylbenzenethiol–>2-Tolylboronic acid–>Toluene
Preparation ProductsTosyl chloride–>Saccharin sodium–>2-Methylbenzene-1-sulfonamide–>2-Chlorobenzoyl chloride–>ETHYL-O-TOLYL KETONE–>2-TOLUENESULFONIC ACID–>2-METHYLPHENYLBORONIC ACID, PINACOL ESTER–>o-Toluenesulfonic acid, methyl ester

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