| 5-Chloro-2-nitroaniline Basic information |
| Description Preparation |
| Product Name: | 5-Chloro-2-nitroaniline |
| Synonyms: | TIMTEC-BB SBB003828;2-AMINO-4-CHLORO-NITROBENZENE;5-CHLORO-2-NITROANILINE;5-chloro-2-nitro-benzenamin;Benzenamine, 5-chloro-2-nitro-;2-NITRO-5-CHLOROANILINE;2-Amino-4-chloro-1-nitrobenzene;5-Chloro-2-nitrophenylamine |
| CAS: | 1635-61-6 |
| MF: | C6H5ClN2O2 |
| MW: | 172.57 |
| EINECS: | 216-661-5 |
| Product Categories: | Pyrimidines;API intermediates |
| Mol File: | 1635-61-6.mol |
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| 5-Chloro-2-nitroaniline Chemical Properties |
| Melting point | 125-129 °C (dec.)(lit.) |
| Boiling point | 200°C (rough estimate) |
| density | 1.5610 (rough estimate) |
| refractive index | 1.5870 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Chloroform, Methanol |
| pka | -1.46±0.25(Predicted) |
| form | Liquid |
| color | Clear colorless to light yellow |
| BRN | 2210201 |
| InChIKey | ZCWXYZBQDNFULS-UHFFFAOYSA-N |
| CAS DataBase Reference | 1635-61-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T+,N,T |
| Risk Statements | 26/27/28-33-51/53 |
| Safety Statements | 28-36/37-45-61-28A |
| RIDADR | UN 2237 6.1/PG 3 |
| WGK Germany | 3 |
| F | 9-23 |
| Hazard Note | Irritant |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29214210 |
| Provider | Language |
|---|---|
| 5-Chloro-2-nitrobenzenamine | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 5-Chloro-2-nitroaniline Usage And Synthesis |
| Description | 2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It has been applied in the upgraded product of veterinary drug albendazole-fenbendazole, and has a broad market prospect. |
| Preparation | Add 2.46mol of 2,4-dichloronitrobenzene, 7.72mol of toluene to a 3L autoclave, seal the autoclave, replace the air with nitrogen, then pass in 14.1mol of liquid ammonia, increase the temperature to 160℃, continue the reaction for 8h, and then lower the temperature to 40℃, drain the excess ammonia gas, open the kettle, add the obtained solid-liquid mixture to 800mL of water, continue to cool to 10℃, filter, add the resulting filter cake to the water, continue beating and filtering, the obtained solid is crystallized with methanol to obtain 388g , yield 91.2%, the purity of the liquid phase external standard is 99.5%. |
| Chemical Properties | yellow to orange powder |
| Uses | 5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates. |
| Uses | 5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity. |
| Application | 5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates. The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. |
| General Description | The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. |
| 5-Chloro-2-nitroaniline Preparation Products And Raw materials |